![]() Chikwe et al ( 5) determined, in a long-term follow-up study, that the mean follow-up time was 10.8 years, and the 15-year survival rate following biological and mechanical valve replacement was as high as 57.5 and 59.9%, respectively. Artificial cardiac valve replacement has effectively improved the life quality of patients and has an important role in the treatment of advanced cardiac valve disease ( 4). INR monitoring is recommended to ensure the safety of the anti-coagulant drug warfarin, but further study is still required to determine a reasonable target INR value.Ĭardiac valve disease is basically an abnormal heart valve structure caused by rheumatic fever, which leads to a disorder of cardiac hemodynamics and impairs the quality of life of affected patients as well as posing a threat to their lives ( 1– 3). The dosage of warfarin, the PT and the INR in the hemorrhage group were all significantly greater than those in the normal group and the embolism group (all P<0.05). ![]() The average dosage of warfarin was 2.0☐.6, 3.1☐.7 and 1.7☐.6 mg/day in the normal, hemorrhage and embolism groups, respectively. ![]() A total of 31 cases (14.6%) developed adverse reactions and complications during the medication period, including 21 cases with hemorrhage (9.9%, hemorrhage group) and 10 cases with embolism (4.7%, embolism group), while 182 patients did not (85.4%, normal group). The warfarin dosage, prothrombin time (PT) and INR were compared among patients with hemorrhage or embolism, and those with no complications. The clinical data of 213 patients who underwent cardiac valve replacement at Linyi Central Hospital (Linyi, China) between January 2010 and May 2013 were retrospectively analyzed. The current study aimed to further explore the INR value of the anti-coagulation drug warfarin after cardiac valve replacement. Thus far, the target value for international normalized ratio (INR) has remained to be determined.
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